How do you handle big data volumes here?

Videos is the toughest since you usually would need

1. Script server

2. Storage server

3. Conversion server

I know that SE probably do not support this setup from basic, and SE was never supposed to be a tube script.

Still- what is best way to handle large databases? I will push away the tube side of things to a separate script (it is a must, SE and tube scripts have two different purposes). User databases will be shared via SSE for users.

you who have bigger sites with +100 TB of data, how do you handle it?

CDN is pretty nice overall like ucdn or storage with wasabi (dont like adult content though).

Me  I am working with larger server for +40 TB for SE script and when that is not enough i most likely will USE UCDN who charges 19 USD per TB of storage and 4 USD TB per CDN streaming, it is pretty fair pricing.

How do you guys who run bigger sites resolve above?

Find a conversion site that could help reduce the video file sizes to reduce storage? 

I used to use Kraken.io for my images.